The extraction method of yohimbine

Pausinystalia Yohimbe is a plant that grows in West Africa and is rich in alkaloids, Yohimbine is the first prescription adrenergic drug approved by the FDA to treat impotence. The adrenergic receptor, which blocks the central nervous system, dilates blood vessels around the genitals, causing complete congestion and eliminating erectile dysfunction. Clinical trials in 1987 showed benefits for 34 to 43 percent of users.

Yohimbine base is a white powder, slightly soluble in water, soluble in ethanol, chloroform, hot benzene, slightly soluble in ether. Yohimbine extracted from yohimbine bark of Ghana can effectively improve male sexual dysfunction. It has been reported that the content of yohimbine alkaloid mixture in the sun-dried Pansinystalia Yohimba bark is more than 6.1%, the main part of which is yohimbine, so the plant extraction has great prospects. There are only two dosage forms of yohimbine drugs on the market, tablets and capsules. Yohimbine has strong pharmacological action, small dose, small molecular weight, and becomes Yohimbine Hydrochloride when it is salted with hydrochloric acid. Its water solubility is greatly improved, and it is easy to penetrate the cuticle of the skin, which is in line with the transdermal treatment system.

At present, in foreign patent reports, the plant extraction method of yohimbine is relatively simple, and its extraction method is similar to that of other total alkaloids. The main extraction process includes: solvent addition extraction; Precipitation of alkaloids; Separation and refining. Most of the lysozymes used are solvent gasoline, chloroform or benzene and other toxic organic solvents. Although the pigment magazine in the extract is less, the solvent residue seriously harms the health of users. Separation and purification can usually be done by physical or chemical methods. When the content is large, alkaloid crystallization or distillation can be used. When the content is low, yohimbine base can be converted into Yohimbine hydrochloride with better water solubility by acid precipitation method, such as ion exchange resin method. Yohimbine hydrochloride is a pure white powder, slightly soluble in water, soluble in ethanol, chloroform, hot benzene, slightly soluble in diethyl ether. At present, there is no patent report on the extraction and refining method of yohimbine hydrochloride in China. Since the isolation of yohimbine in 1900, drug workers have been studying the chemical structure and properties of yohimbine for many years. Finally, in 1943, the stereoscopic structure of yohimbine was determined, and the degradation pathway was clarified. Yohimbine was first chemically synthesized by WoodWard in 1958, and since then the synthesis route has been continuously refined.