The difference between nimodil and felodipine
Nimodidi and felodipine are both calcium channel blockers. Calcium channel blockers are widely used in the treatment of hypertension, angina pectoris, arrhythmia and other diseases due to their strong antihypertensive effect and good tolerance. However, there are many differences in pharmacological mechanisms and indications between nimodidi and felodipine.
Different pharmacological mechanisms
Nimodipine is a calcium channel blocker. The contraction process of smooth muscle cells depends on calcium ions, which enter these cells as slow ionic transmembrane currents during depolarization. Nimodipine inhibits calcium transfer into these cells, thereby inhibiting vascular smooth muscle contraction.
Felodipine is a member of the dihydropyridine class of calcium channel antagonists (calcium channel blockers). The effect of felodipine on Blood Pressure is primarily a dose-dependent reduction in human peripheral vascular resistance with a modest increase in reflex heart rate. In addition to the mild diuretic effects found in several animals and humans, the effects of felodipine are mainly reflected in its effect on peripheral vascular resistance. Different indications
Nimodipine can be used clinically for subarachnoid hemorrhage, ischemic cerebrovascular disease, migraine, senile brain dysfunction, mild to moderate hypertension, sudden deafness.
Felodipine can be used clinically for hypertension and stable angina pectoris.
Contraindications vary
Nim horizon
It is forbidden if you are allergic to this product or any ingredient in this product.
The combination of nimodipine and rifampicin significantly reduces the efficacy of nimodipine, so nimodipine should not be used in combination with rifampicin.
The combination of oral nimodipine with the antiepileptic drugs phenobarbital, phenytoin, or carbamazepine significantly reduces the efficacy of nimodipine, so the combination is prohibited.
When used in the treatment of senile brain dysfunction, nimodipine may be more bioavailable in patients with severely impaired liver function, especially in patients with cirrhosis, due to first-pass effects and reduced metabolic clearance. It is therefore contraindicated in patients with severely impaired liver function (e.g., cirrhosis);
Nim horizon and inhibitor of CYP3A4 preparations such as some large ring lactone class Antibiotic (e.g., clarithromycin, tillie toxin), some HIV protease inhibitors, such as pulling wei organism, indene that wei, nelfinavir, so wei, ShaKui that wei), some azole antifungal drugs (such as ketone health zun, itraconazole, voriconazole) and some antidepressants (e.g., nefazodone) is prohibited Concurrent use because of the risk of significant hypotension.
Xi'an Henrikang Biotech Co., Ltd., steroids Product adhere to innovation, always produce high-quality products.The company has standard GMP production workshop, perfect extraction equipment and chemical synthesis equipment, in extraction, purification, drying, packaging and other links, Organic Extract have excellent quality. Our Pesticides And Insecticides have been recognized by the majority of enterprises producing Essential Oil , we always take customer first, put customer experience in the first place.
Xi'an Henrikang Biotech Co., Ltd., has a high-quality talent team and well-equipped quality control laboratory. In the Skin Whitening enterprises far ahead of other enterprises.we are also a high-quality supplier, absolutely reliable quality, absolutely competitive price. The factory has a RESEARCH and development and quality testing center, with strong technical research and development strength. Food Supplement also has 3 sales departments, more than 30 people, and our pure natural Extract are sold all over the world.Body Building Product sales in foreign countries our company has a long-term stable market and partners in Enzyme Products, We are very professional suppliers, looking forward to cooperating with you, welcome to consult us.
