Vitamin K2 is A Natural Vitamin Containing
Vitamin K2 is a natural vitamin containing menadione basic structure and anti-bleeding effect, yellow crystal or oily liquid at room temperature, insoluble in water, easily soluble in organic solvents and vegetable oil, heat resistant, but easy to be destroyed by light. It can promote the synthesis of prothrombin in liver, regulate the synthesis of coagulation factors ⅶ, ⅸ, ⅹ, and accelerate blood coagulation. In addition, it plays an important role in intracellular phosphorylation of glucose. In some bacteria, such as Mycobacteria, it is a component of the respiratory chain. After deficiency, the clotting time is prolonged, so in the case of trauma, bleeding will not stop. Human and animal intestinal bacteria can be synthesized, so it is generally not easy to get deficiency disease. 
It's found in liver, fish, meat and green leafy vegetables like cabbage and spinach. 2,3 epoxides of vitamin K are metabolites of vitamin K2 in the liver, which are produced in large quantities in animals treated with acetone benzylcoumarin (warfarin). The anticoagulant effect of benzyl coumarin in acetone is to inhibit the reductase that reduces epoxide to vitamin K, thus blocking the conversion of vitamin K and its epoxide in the body, and stopping the activity of vitamin K2 in the synthesis of thrombin element. Vitamin K2 is also involved in REDOX action in the body and is a component of the respiratory chain, located between flaviase and cytochrome, involved in electron transport and oxidative phosphorylation processes.
When vitamin K was deficient, the content of ATP and phosphocreatine and the activity of ATPase in muscle decreased significantly. Vitamin K increases intestinal peristalsis and secretion function, lack of vitamin K in smooth muscle extension and contraction ability is weakened. Action AND USE NATURAL VITAMIN K1 AND VITAMIN K2, respectively from plant food and produced by intestinal bacteria, is fat soluble, need bile to assist absorption. The synthetic vitamins K3 and K4 are water-soluble and do not require bile to assist absorption. Vitamin K is an essential substance for the synthesis of coagulation factors ⅱ, ⅶ, ⅸ and X, thus promoting the coagulation process. When vitamin K is deficient, the synthesis of the above coagulation factors is impaired, which affects the coagulation process and causes bleeding. It also has analgesic effect, which may be mediated by opioid receptors and endogenous opioid substances.
It is suitable for hemostasis: obstructive jaundice, biliary fistula, chronic diarrhea, neonatal and premature hemorrhage, secondary vitamin K deficiency caused by long-term application of broad-spectrum antibiotics and sulfasamide, and hemorrhage caused by excessive application of coumarins and salicylic acids. Analgesia: Used for cholelithiasis, biliary ascaris caused by biliary colic. A large dose can relieve the poisoning of sodium dionychium. The overuse of broad-spectrum antimicrobials inhibits the synthesis of vitamin K2 by intestinal bacteria, and liver diseases reduce the synthesis of prothrombin and other coagulation factors.
