Use of budesonide: 1. Induce the synthesis of lipidin and inhibit phospholipase A2, and reduce the production and release of lipid inflammatory mediators such as plateletactivating factor, leukotrienes and prostaglandins generated by membrane phospholipid hydrolysis catalyzed by this enzyme. 2. Induced the expression of angiotensin Ⅰ convertase and neutral peptide endonuclease, accelerated the production of angiotensin Ⅱ, and the degradation of bradykinin and tachykinin, respectively; Inhibit the expression of nitrous oxide synthetase and reduce the production of nitrous oxide. Thus constricting blood vessels, or reduce the vasodilatation, inflammation, neurogenic inflammatory reaction and other effects of other active substances in addition to vascular tension Ⅱ. In addition, it can induce the production of vasocortin, a vasoconstrictor substance.
3. Inhibit the expression of various cytokines, such as interleukin-1, 3, 4, 6, 8, tumor necrosis factor, granulocyte colony-stimulating factor. Reduce the effect of the above factors on airway inflammation, especially chronic inflammation. 4. Promote the expression of adrenergic β2 receptor and improve the sensitivity to endogenous and exogenous medicinal β2 receptor agonists. 5. Immunosuppressive effect: It has inhibitory effect on the whole immune process from antigen phagocytosis treatment, lymphocyte division, proliferation, differentiation, to the effect period.
